Hardwick voiced Alexander Hamilton in The Radio Adventures of Dr.
Floyd and Otis in the Barnyard series (the character was originally voiced by actor Kevin James in the movie Barnyard: The Original Party Animals).
Thomas Lennon and Robert Ben Garant, formerly of Reno 911! Hardwick is also a stand-up comedian and performs with Mike Phirman in the music comedy duo Hard 'n Phirm, whose half-hour comedy special Comedy Central Presents: Hard 'n Phirm premiered in January 2008.
In 2007, both his solo standup and duo act were featured on the comedy compilation CD Comedy Death Ray.
In 2013, Hardwick hosted Talking Bad, a live half-hour talk show on AMC following the final eight episodes of Breaking Bad, and in 2016 he started to host Talking Saul for Breaking Bads spin-off, Better Call Saul.
He is also known for performing with Mike Phirman in Hard 'n Phirm, hosting Singled Out, Wired Science, Web Soup, and Nerdist Podcast, and as the voice of Otis in Back at the Barnyard, replacing Kevin James.
The deal also included Hardwick doing intros and outros for BBC America's new Saturday-night Ministry of Laughs comedy block of Britcoms.