Stone collaborated with jazz pianist Herbie Hancock and blues singer-guitarist Jonny Lang on a cover of U2's 1988 song "When Love Comes to Town" for Hancock's 2005 album Possibilities.That same year, Stone was featured along with Sean Paul on Santana's "Cry Baby Cry", and worked on a remake of Patti La Belle's 1985 song "Stir It Up" for the soundtrack to the Disney animated film Chicken Little.Stone, who was born two years after the release of the original single, was not initially aware of who Bob Geldof was. At the 2005 BRIT Awards, Stone won for British Female Solo Artist and British Urban Act—entering the Guinness World Records as the youngest BRIT Award solo winner at age seventeen, and was nominated for British Breakthrough Act.
Stone's third album, Introducing Joss Stone, released in March 2007, achieved gold record status by the RIAA and yielded the second-ever highest debut for a British female solo artist on the Billboard 200, and became Stone's first top five album in the US. , on 20 October 2009, which reached the top 10 on Billboard.
Stone released her fifth album, LP1, on 22 July 2011, which reached the top 10 on Billboard.
The group, consisting of such luminaries as Coldplay lead singer Chris Martin and U2 lead singer Bono, re-recorded the 1984 song "Do They Know It's Christmas?
", written by Band Aid organisers Bob Geldof and Midge Ure.
Their performance of "Cry Baby/Piece of My Heart" was released as a single, and through the aid of strong digital download sales, became Stone's first single to enter the US Billboard Hot 100, when it debuted and peaked at No. By that time, rumours circulated about her being dropped from the campaign because she was living with then-25-year-old songwriter and producer Beau Dozier (son of Motown producer and composer Lamont Dozier) in Los Angeles while she was only 17.