Simpson starred with her then-husband Nick Lachey in the MTV reality show Newlyweds: Nick and Jessica. She auditioned for the Mickey Mouse Club and made it to the finals at the age of twelve. Soon afterward her album Sweet Kisses was released.
During the summer of 2003, the reality show, Newlyweds: Nick and Jessica, starring Simpson and her then-new husband Nick Lachey began airing on MTV.
Simpson's third album, In This Skin, was released in August of 2003 to coincide with the series premiere of Newlyweds.
She starred as “Tracy Cooper” in the NBC sitcom Truth Be Told (2015).
Her television credits also include Wipeout, CSI: NY, 30 Rock, Hawaii Five-0 and Psych.
She has been ranked on Maxim’s annual Hot 100 issue a few times.